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TAK-243 preferentially certain to UBA1 more than the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced levels of ubiquitylated proteins, enhanced markers of proteotoxic strain and DNA hurt worry. In vivo, TAK-243 diminished leukemic stress and specific leukemic stem cells without having proof of